Nutraceuticals
Patented and preclinically supported extract that supports the function of the gastrointestinal system
(Olea europea L.)
Strengthening the integrity of the intestinal barrier
Reducing low-grade inflammation
Supports intestinal immune balance
Optimises the gut microbiome's composition
Beneficial actions observed in preclinical studies (7,8,9,10)
Why Oligut
Supports the function of the gastrointestinal system
More than 40% of people worldwide suffer from chronic gastrointestinal problems (1)
Digestive diseases have a major global impact, with 7.32 billion incidents and 2.86 billion prevalent cases (2)
Gut inflammation is a key driver of many digestive disorders, as it can weaken the intestinal barrier and lead to digestive discomforts (3)
Gut inflammation can also interfere with digestion and promote the development of conditions such as IBD and IBS (4)
The Gut Health Nutraceuticals Market size was estimated at 12.24 billion USD in 2024 (5)
In vivo and In vitro studies
Several preclinical in vivo and in vitro studies were conducted in species with high translational relevance to humans.
Reduce inflammation
Enhance the integrity of the intestinal barrier
Modulate the immune response
Improve gut microbiota
Animals that were fed OLIGUT ™ after the administration of the inflammatory agent showed a significant reduction in colon injury and inflammation(8).
Reduce inflammation
Supplementation with OLIGUT ™ in animals with LPS-induced inflammation reduced the inflammatory response by reducing IL1β levels in vivo, suggesting improved digestive and systemic well-being(7).
The bioactive olive extract rescued and even enhanced the expression of CDH1, the gene encoding the epithelial adhesion protein E-cadherin in a model of chronic inflammation, reflecting restoring of cell junctions and barrier maintenance or healing(7).
Enhance the integrity of the intestinal barrier
OLIGUT ™ supplementation showed significantly higher plasma mannitol concentrations indicating improved nutrient absorption and reduced intestinal permeability suggesting better intestinal integrity(7)
Modulate the immune response
In LPS-challenged animals, OLIGUT ™(9):
• Helped modulate the systemic inflammatory response, preventing an overreaction of the immune system.
• Showed a protective effect against inflammation induced damage that contributed to a faster recovery of the immune system.
Improve gut microbiota
OLIGUT ™ treatment in vitro helped modify the intestinal microbiota composition in several ways(10):
• By reducing the levels of pro- inflammatory or potentially pathogenic bacteria
• Increasing beneficial bacterial groups such as Lactobacillus spp and Bacteroides spp
• Suggesting a selective prebiotic and antimicrobial effect
Applications
Supplements
Confectionary
Powders
Sources
- (1)Sperber, A.D., et al. Gastroenterology, 2021, 160(1), 99-114;
- (2)Wang, Y. et al. Gastroenterology, 2023, 165(3), 773-783;
- (3)Lechuga, S. et al. Biochim Biophys Acta Mol Cell Res, 2017, 1864(7), 1183-1194;
- (4)Pérez de Arce, E. et al. Gastroenterol Hepatol, 2022, 45(1), 66-76;
- (5)Gut Health Nutraceuticals Market by Product, Form, Distribution Channel – Global Forecast to 2030. Report no. 5910264, 2025, 360iResearch;
- (6) Patent: Quintela et al. 2019. Combination of pentacyclic triterpenes and polyphenols and derivatives thereof.(US 10,376,529 B2);
- (7)Liehr, M. et al. PLoS One, 2017, 12(3):e0174239;
- (8) INNOFENOL project;
- (9)Cangiano, L.R. et al. J Anim Sci, 2019, 97(10), 4349-4361;
- (10)BIOADA project
Tuesday, November 18, 2025
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