Nutraceuticals
Apple and olive extract that helps balance factors related to metabolic syndrome
Standardised to apple-derived polyphenols and triterpenic compounds from olives
Decreases adipose tissue and increases muscular mass
Reduces waist circumference
Supports physiological sugar balance
Contributes to the prevention of high triglycerides
Metabolic Syndrome
Metabolic Syndrome (MS) denotes a cluster of conditions that increase the risk of heart disease and other health issues, such as diabetes and stroke probability.
It has been estimated that approximately 10-30% of the world’s adult population has MS. In the United States and Europe the prevalence is higher, ranging from 22-24%.
Preclinical studies
Natac internal preclinical studies showed the synergistic effect of apple and olive combined is significantly greater on glucose and lipid profile than the ingredients by themselves.
Lumbar adipose tissue
Basal serum glucose
Triglycerides serum levels
Figure 1. Lumbar adipose tissue in obese mice (ob/ob, OB) and obese mice treated with POMOLIVE by Natac (OB+POMOLIVE by Natac) after 6 weeks of treatment. * p<0.05 vs. Obese.
Lumbar adipose tissue
Pomolive by Natac significantly reduced the increase in lumbar adipose tissue in obese mice
The presence of fat deposits is significant in explaining the link between the distribution of body fat and the occurrence of cardio-metabolic risk factors and coronary artery disease.
Figure 2. Basal glycemia in obese mice (ob/ob, OB) and obese mice treated with POMOLIVE by Natac (OB+POMOLIVE by Natac) after 6 weeks of treatment. * p<0.05 vs. Obese
Basal serum glucose
Pomolive by Natac normalised increased basal serum glucose levels in obese mice
Type 2 diabetes is a progressive disease characterised by hyperglycemia preceded by insulin resistance or diminished sensitivity of β-cell to insulin caused by various metabolic anomalies, including obesity
Figure 3. Serum triglycerides in obese mice (ob/ob, OB) and obese mice treated with POMOLIVE by Natac (OB+POMOLIVE by Natac) after 6 weeks of treatment. * p<0.05 vs. Obese.
Triglycerides serum levels
Pomolive by Natac reduced triglycerides serum levels in obese mice
During periods of increased energy demand, triglycerides stored in adipose tissues are immediately released via lipolysis.
Lipolysis is also involved in the pathogenesis of metabolic disorders; recent studies in humans have underscored its role in disease states such as obesity-induced insulin resistance.
Clinical Studies
The efficacy of Pomolive on factors related to metabolic syndrome was demonstrated in a prospective, randomised, double-blind, placebo-controlled study conducted internally by Natac in 60 subjects who received a daily dose of 500mg of Pomolive by Natac (250 mg twice daily). Supplementation with Pomolive by Natac in this study showed:
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Lower body weight
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Reduction of body mass index
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Production of adipose tissue loss
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Stimulation of muscular mass gain
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Induced waist circumference reduction
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Controlled serum glucose
Figure 4. Body weight, Kg (A), Body mass index (BMI), Kg/m2 (B), Adipose tissue,% (C), Muscular mass gain, % (D), Waist circumference, cm (E) and Serum glucose, % (F) in Placebo and POMOLIVE by Natac treated subjects after 8 weeks of treatment. * p<0.05 vs Placebo.
References: Alberti KG et al. Circulation, 2009. Alberti KG et al. Lancet, 2005. Arner P et al. Trends in Endocrinology and Metabolism, 2014. Beltrán-Sánchez et al. J Am Coll Cardiol, 2013. Ford ES et al. J Diabetes, 2010. Luna-Luna M et al. Archives of Medical Research, 2015. Mulè et al. World Journal of Cardiology, 2014. Rask-Madsen C et al. Arterioscler Thromb Vasc Biol., 2012.
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