Nutraceuticals
Olive fruit extract for a Natural Cardiovascular Protection.
Helps the physiological sugars balance
Keeps normal blood pressure
Management of cardiovascular health
Cardiovascular Disease
Cardiovascular disease (CVD) is a significant, ever-growing worldwide problem. Globally, CVD accounts for 31% of all deaths and, 80% of them occur in developing nations. Not only is it a prime cause of mortality, but it is also the leading reason for disability-adjusted life years lost globally.
Behavioral risk factors (unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol) may show up in individuals as high blood pressure, elevated blood glucose and lipids, and overweight and obesity.
Preclinical studies
Our preclinical studies prove Endolive’s potential cardiovascular benefits based on the observed effects on hypertension, arterial function and remarkably improved cardiac function in hypertensive rats.
Blood pressure
Arterial function
Cardiac function
Figure 1. Systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR) and spontaneously hypertensive rats treated with Endolive (SHR+Endolive) after 8 weeks of treatment* p<0.05 vs. SHR
Endolive lowered systolic blood pressure in hypertensive rats
Endolive significantly lowers elevated systolic blood pressure in hypertensive rats.
Hypertension is one of the significant risk factors for cardiovascular disease. This generates functional and structural changes in the arterial wall and target organs (heart, kidney, brain).
Figure 2. Collagen I protein expression in spontaneously hypertensive rats (SHR) and spontaneously hypertensive rats treated with Endolive(SHR+Endolive) after 8 weeks of treatment *p<0.05 vs. SHR.
Endolive presserved arterial function in hypertensive rats
Endolive reduces aortic collagen I protein expression in hypertensive rats.
The accumulation of collagen induces fibrosis which can lead to aortic wall stiffness and arterial dysfunction. Therefore, it has been postulated as one of the most relevant vascular changes involved in the progression of hypertension.
Figure 3. Left ventricle end-diastolic pressure (LVEDP) in spontaneously hypertensive rats (SHR) and spontaneously hypertensive rats treated with Endolive (SHR+Endolive) after 8 weeks of treatment *p<0.05 vs SHR.
Endolive improved cardiac function in hypertensive rats
Endolive improves cardiac function by decreasing elevated left ventricular end-diastolic pressure in hypertensive rats.
Not only vessels but also the heart is a prime target for hypertensive damage. Uncontrolled hypertension accelerates the injury, which results in eventual heart dysfunction.
Clinical studies
A randomized study conducted on 60 volunteers, of whom 30 were given 200mg/day of ENDOLIVE for 8 weeks, revealed that it helped maintain a healthy cardiovascular system. The study observed:
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Control of high systolic blood pressure
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An increase in serum HDL cholesterol
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A reduction in serum glucose
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A reduction in the cardiovascular risk score
Figure 4. Systolic blood pressure (SBP) (A), Serum glucose (B), Serum HDL-Cholesterol (C), and Cardiovascular risk score (Framingham Risk Score – 10-year risk prediction) (D) in Control and Endolive-treated subjects aftereight weeks of treatment. * p<0.05 vs Control
Pharmacokinetics
Endolive’s pharmacokinetic profile has been defined in human volunteers. Its bioavailability has been reported in terms of oleanolic acid and maslinic acid. In addition, significant amounts of triterpenes were found in healthy subjects when Endolive was administered acutely at a dosage of 200mg.
References: Valero-Muñoz et al., Mol. Nutr. Food Res., 2014, Stewart et al., JRSM Cardiovasc Dis. 2017, WHO.
Cardiovascular diseases (CVDs). 2016, Mahmood etal., The Lancet 2014, Wilson et al. Circulation 1998, Yusuf et al. The Lancet 2004.
Dosage
200 mg/day
Suggested galenic form
Softgel capsules formulated with virgin olive oil as carrier. 2 capsules per day.
Patents
EP3007687; US2016143930; CA2915164; CN105530922; JP2016521717; WO2014198842; EP2305783;
US8361518; NZ590649; MX2011000786; JP5512671; ES2332977;CA2731917; AU2009273171 .
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